万鸿平等

    [摘要] 目的 探讨无症状性颈动脉狭窄(ACS)患者认知功能障碍的特点，研究支架植入联合药物治疗和单纯药物治疗对ACS患者认知功能的影响。 方法 选取湖北省中山医院神经内科ACS患者192例(ACS组)和颈动脉无狭窄患者100例(对照组)，ACS组按狭窄程度分为轻度、中度、重度三组，比较认知功能的差异；将重度狭窄患者随机分为A组(支架植入联合药物治疗)、B组(药物治疗)，检测A、B组在治疗前、治疗后1个月、治疗后3个月、治疗6个月认知功能的变化。 结果 ①ACS组与对照组、A组与B组的基线情况比较差异无统计学意义(P > 0.05)；②ACS组与对照组比较认知功能下降(P 0.05)。A组较B组治疗后1、3、6个月认知功能改善更明显(P < 0.05)。 结论 ACS患者存在认知功能障碍，狭窄程度越重认知功能损害越明显，对于重度狭窄患者，支架植入+药物治疗可改善认知功能。

    [关键词] 无症状性颈动脉狭窄；支架植入；药物治疗；认知功能

    [中图分类号] R543.5 [文献标识码] A [文章编号] 1673-7210(2015)05(b)-0057-05

    Changes of cognitive function in patients with asymptomatic carotid stenosis

    WAN Hongping DENG Xiaorong DU Min KE Wei

    The First Department of Neurology， Zhongshan Hospital， Hubei Province， Wuhan 430031， China

    [Abstract] Objective To investigate the features of cognitive impairment in patients with asymptomatic carotid stenosis and to research effect of treatment on cognitive functions by stenting implantation combined with drug therapy and simple drug. Methods 192 case of patients with ACS in Department of Neurology， Zhongshan Hospital (ACS group) and 100 cases of patients without carotid stenosis (control group ) were chosen. ACS group was divided into mild ......