索拉非尼纳米混悬剂的稳定性研究
张英 张洪 彭锐![](https://cimg.fx361.com/images/2018/03/23/yycy201515yycy20151531-1-l.jpg)
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[摘要] 目的 研究索拉非尼纳米混悬剂的物理稳定性和化学稳定性。 方法 观察不同温度和时间下纳米混悬剂的粒径和多分散指数(PDI)的变化,并用HPLC对不同时间内索拉非尼纳米混悬剂的浓度进行测定并绘制其降解曲线。 结果 索拉非尼纳米混悬剂避光放于4℃下物理稳定性良好,粒径和PDI变化不大;索拉非尼纳米混悬剂与溶解状态的索拉非尼相比,化学稳定性显著改善,有效药物浓度的降解速度明显降低。 结论 将索拉非尼制成纳米混悬剂稳定性显著改善,可长期保存。
[关键词] 索拉非尼;纳米混悬剂;物理稳定性;化学稳定性
[中图分类号] R965 [文献标识码] A [文章编号] 1673-7210(2015)05(c)-0120-04
[Abstract] Objective To investigate the physical stability and chemical stability of Sorafenib Nanosuspension. Methods The change of size and PDI under different temperature and time were observed. The concentration of Sorafenib in different time was determined by using HPLC and its degradation curve was drawed. Results Sorafenib Nanosuspensions had little change in particle size and PDI, had a good physical stability in the dark at 4℃. The degradation rate of Sorafenib Nanosuspension highly decreased compared with the reference methanol solution of Sorafenib ......
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