早期快速反应基因5在宫颈癌放疗辐射敏感性中的研究进展
刘洋 吴玉梅[摘要] 低辐射敏感性是造成宫颈癌复发率高的重要原因之一。如何提高放疗敏感性进而增强放疗效果,一直以来困扰着临床医师。近年来,随着医学分子生物学技术水平的不断进步,现已发现有关肿瘤细胞增殖、调控以及凋亡的多条分子通路,为探究宫颈癌辐射敏感性机制提供了良好的平台。早期快速反应基因5(IER5)作为肿瘤相关因子的一员,已有研究证实,其在多种肿瘤细胞中发挥着抑制细胞增殖、促进凋亡以及增强肿瘤细胞辐射敏感性的作用。因此,IER5基因有可能成为宫颈癌放射治疗的新靶点,具有潜在的临床使用价值,值得深入研究。
[关键词] 早期快速反应基因5;宫颈癌;放射治疗;辐射敏感性
[中图分类号] R737.33 [文献标识码] A [文章编号] 1673-7210(2015)09(c)-0035-04
[Abstract] Low radiation insensitivity is one of the high recurrence factors in cervical cancer radiotherapy. How to enhance radiation sensitivity and then improve the efficacy of radiotherapy has long remained an important obstacle in clinic. In recent years, the constant evolution of molecular biology technology has led to more discoveries about the pathways of cancer cell proliferation, regulation and apoptosis from gene level, which provide a good platform for exploring radiation sensitivity mechanism of cervical cancer. Existing studies have confirmed, immediate-early response gene 5 (IER5), as a member of tumor correlation family, can suppress proliferation, accelerate the apoptosis as well as increase the radiation sensitivity in a wide variety of tumor cells. Therefore ......
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