彭珊 赵钢 李春艳

    [摘要] 肠易激综合征(IBS)是一种以腹痛或腹部不适伴排便习惯改变为特征的功能性胃肠病，其发病机制尚未完全阐明。近年来对IBS发病机制的研究取得了实质性进展，认为IBS由多种因素引起，包括异常肠道黏膜细胞及神经递质、胃肠动力、内脏高敏感、肠道感染、小肠细菌过度生长、脑肠轴、精神心理因素、饮食因素等。

    [关键词] 肠易激综合征；发病机制；动力异常；内脏高敏感性

    [中图分类号] R574 [文献标识码] A [文章编号] 1673-7210(2016)02(c)-0054-04

    Advances in the pathogenesis of irritable bowel syndrome

    PENG Shan ZHAO Gang LI Chunyan

    Department of Gastroenterology， the First Affiliated Hospital of Dalian Medical University， Liaoning Province， Dalian 116011， China

    [Abstract] Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by abdominal pain and discomfort associated with altered bowel habits. But the exact cause and the pathogenesis of IBS are poorly understood now. Recent years have witnessed substantial progress in our understanding of pathophysiology of IBS. Multiple factors， like genetic factors， gastrointestinal dysmotility， visceral hypersensitivity， intestinal infection， small intestinal bacterial overgrowth (SIBO)， the brain-gut axis，psychological factors， and so on.

    [Key words] Irritable bowel syndrome； Pathogenesis； Dysmotility； Visceral hypersensitivity ......