宋洪美 何田丽 马建新蚌埠医学院附属连云港第二人民医院放射治疗科，江苏连云港 222000

    自噬在肿瘤放射增敏中的研究进展

    宋洪美何田丽马建新

    蚌埠医学院附属连云港第二人民医院放射治疗科，江苏连云港222000

    细胞自噬是进化上相对保守的过程，在细胞的生长、分化及维持内稳态等方面都扮演着重要角色。研究表明，细胞自噬与人类肿瘤的发生、发展密切相关，并有助于放射中的抗肿瘤作用。在肿瘤治疗中放射治疗是一个非常有效的治疗方法，然而，大部分肿瘤存在放疗抵抗。放疗受很多因素的影响，如肿瘤组织的乏氧程度、DNA损伤修复能力及肿瘤干细胞的存在等。本研究回顾自噬与放疗间的关系发现，以上三种因素很可能是放疗中自噬的潜在分子机制，并探讨了临床中这些关系和机制的治疗意义。

    自噬；放疗敏感性；乏氧；DNA损伤；肿瘤干细胞

    [Abstract]Autophagy is a relatively conservative process，which plays an important role in cell growth，differentiation and maintaining homeostasis.Studies have indicated that autophagy is closely related to the occurrence and development of human cancer，and contributes to the antineoplastic effects of radiation.Radiation is an important strategy in cancer treatment.However，many types of cancer show radioresistance.The effects of radiotherapy are affected by factors，including the degree of tumor tissue hypoxia，the ability to repair DNA damage，and the presence of cancer stem cells.This article reviews the relationships between autophagy and radiotherapy，find that the three factors in cancer radiation maybe the possible underlying molecular mechanisms of autophagy.The therapeutic implications of these relationships and mechanisms in clinical settings are also discussed. ......