血胎球蛋白A水平与慢性肾脏病5期未透析患者血管钙化的相关性
刘凌 陈瑶 杨英[摘要] 目的 分析慢性肾脏病5期未透析(CKD-5ND)患者血管钙化相关因素,探讨外周血胎球蛋白A(Fetuin-A)水平对血管钙化的预测价值。 方法 选取2015年1月~2016年2月内蒙古巴彦淖尔市医院肾内科CKD-5ND患者53例(CKD-5ND组),同时选取年龄、性别相匹配的健康体检者25例作为对照组。采用彩色多普勒超声仪及脊柱侧位X线检测颈动脉及腹主动脉血管钙化情况。按照有无钙化将CKD-5ND组患者分为肾病无钙化组(25例)和肾病钙化组(28例)。使用双抗体夹心酶联免疫法(ELISA)检测三组血清Fetuin-A水平;比较三组有关参数及Fetuin-A水平的变化,探讨其相关性并分析其临床意义。 结果 与对照组比较,CKD-5ND患者血清Fetuin-A水平明显下降(P 0.05)。相关性分析显示,肾病钙化组患者血清Fetuin-A与Scr(r = -0.416,P 0.05)。 结论 CKD-5ND患者血清Fetuin-A水平显著低于正常人群,但与其血管钙化的关系尚不确定。血清Fetuin-A水平与患者体内微炎性反应状态关系密切。
[关键词] 胎球蛋白A;慢性肾脏病5期未透析;血管钙化;相关性
[中图分类号] R692.5 [文献标识码] A [文章编号] 1674-4721(2016)10(b)-0024-04
[Abstract] Objective To analyze the relative factors of vascular calcification in patients with non-dialysis stage 5 chronic kidney disease (CKD-5ND), and explore the predictive value of serum fetuin-A in their vascular calcification. Methods A total of 53 cases of CKD-5ND patients from January 2015 to February 2016 in Nephrology Department of Inner Mongolia Bayannaoer City Hospital were selected in this study (CKD-5ND group), 25 cases of age, gender matched patients were selected as the control group. Color doppler ultrasound was used to detect carotid artery calcification ......
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