赵青芳+关露露+陈小兵

    [摘要] 长链非编码RNA(lncRNAs)是一类转录本长度大于200 nt的非编码RNA，不具备蛋白质编码功能。研究发现lncRNA异常表达与胃癌有关。在表观遗传学水平上，lncRNAs可通过与mRNA碱基互补配对形成双链或与RNA结合蛋白(RBP)形成复合物，介导mRNA剪接和稳定性；也可与微小RNA(miRNA)形成竞争性內源RNA(ceRNA)调控网络，参与基因表达调控；在某些情况下，lncRNAs招募组蛋白修饰复合物，抑制靶基因的转录；此外，lncRNAs还可通过肿瘤抑制基因P53或癌基因c-Myc发挥致癌或抑癌作用。同时，lncRNAs参与胃癌发生发展过程中的信号转导通路，调节上皮-间质转化(EMT)过程影响转移。本文就lncRNA在胃癌中的作用机制的研究进展作一综述。

    [关键词]长链非编码RNA；胃肿瘤；表观遗传；上皮间质转化

    [中图分类号] R735.2 [文献标识码] A [文章编号] 1673-7210(2017)03(b)-0033-04

    Mechanism of long non-coding RNAs in gastric cancer

    ZHAO Qingfang GUAN Lulu CHEN Xiaobing

    Department of Gastroenterology， Tumor Hospital Affiliated to Zhengzhou University， He'nan Province， Zhengzhou 450003， China

    [Abstract] Long non-coding RNAs (lncRNAs) are non-coding RNAs that have transcript lengths exceeding 200 nt and do not have the capacity for protein coding. Aberrant expression of lncRNAs has been found associated with gastric cancer. At the level of epigenetics， lncRNAs may mediate mRNA stability and splicing by complementary base pairing with mRNAs or forming complexes with RNA binding proteins (RBPs)； lncRNAs also participate in the competing endogenous RNA (ceRNA) network with miRNA； under certain circumstances ......