赵岩+++吕涌涛

    [摘要] 尿激酶型纤溶酶原激活物，简称尿激酶(uPA)是纤溶酶原的主要激活物之一。近年来的研究发现尿激酶在多种病理和生理过程中发挥了重要作用，包括创伤愈合、组织再生、细胞迁移，特别是癌症转移和血管生成等多种病理和生理过程。同时，尿激酶在神经系统疾病中广泛应用，包括溶栓和颅内血肿微创穿刺术中作为血肿液化剂使用。结合笔者工作，本文对尿激酶对脑组织的影响进行综述。

    [关键词] 尿激酶；脑组织；神经损伤修复；脑损伤；研究进展

    [中图分类号] R74 [文献标识码] A [文章编号] 1673-7210(2017)04(b)-0043-04

    [Abstract] Urokinase type plasminogen activator (uPA) is one of the major activators of plasminogen. Recent studies have found that urokinase played an important role in physiological and pathological processes， including wound healing， tissue regeneration， cell migration， especially the physiological and pathological process of cancer metastasis and angiogenesis. At the same time， urokinase is widely used in the nervous system diseases， including the use of thrombolysis and intracranial hematoma minimally invasive surgery as a hematoma liquefaction agent. In this paper， the effects of urokinase on brain tissue were reviewed.

    [Key words] uPA； Brain tissues； Repair of nerve injury； Brain injuries； Research progress

    尿激酶型纤溶酶原激活物，简称尿激酶(urokinase，uPA)是纤溶系统的重要一员。uPA是一种特异性丝氨酸蛋白酶，可以被多种类型细胞合成 ......