梁悦+张光涛+汤晓萌+王迎春+刘玉琴+史君

    [摘要] 目的 探讨从心血管压力负荷增加到心肌肥厚形成的全过程中收缩压和心重指数的变化。 方法 选用健康雄性Wistar大鼠80只，随机分为假手术组与腹主动脉缩窄组，每组各40只。两组大鼠分别随机分配到4个时间点(术后3 d、1周、2周和4周)，各10只。参照腹主动脉缩窄术制作压力负荷性心肌肥厚大鼠模型，大鼠收缩压采用无创尾动脉血压测定分析系统进行测量，电子天平称量左心室重和体重，随后计算心重指数(LVW/BW)。 结果 与假手术组相比较，腹主动脉缩窄组术后3 d时，即表现出收缩压升高，差异有统计学意义(P < 0.05)；在术后1周，收缩压继续升高，心重指数开始增加，差异有统计学意义(P < 0.05)；术后2、4周，收缩压和心重指数继续增加，差异有统计学意义(P < 0.05)。 结论 大鼠造模1周时开始出现心肌肥厚，模型在4周时比较稳定，利用腹主动脉缩窄术制作压力超负荷心肌肥厚大鼠模型成功。

    [关键词] 心肌肥厚；腹主动脉缩窄术；收缩压；心重指数

    [中图分类号] R542.2；R332 [文献标识码] A [文章编号] 1673-7210(2017)05(b)-0016-04

    [Abstract] Objective To discuss the change of systolic pressure and heart weight index (HWI) in the process of cardiovascular pressure overload to myocardial hypertrophy. Methods 80 healthy male Wistar rats were randomly divided into two groups， sham operation group and abdominal aorta group. Each group was randomly separated to 4 time points (3 d， 1 week， 2 weeks， 4 weeks after surgery). Hypertrophy rats model was made by transverse aortic constriction (TAC)， systolic blood pressure was measured by noninvasive tail arterial blood pressure measurement and analysis system. The weight of the left ventricular and body was measured by an electronic balance ......