氨甲环酸治疗狄波—普维拉所致的子宫不规则出血的效果
张雪 李天人 郭毅[摘要] 目的 探索使用氨甲环酸治疗狄波-普维拉(DMPA)所致的子宫不规则出血(IUB)的疗效与安全性。 方法 选择2015年12月~2016年12月中国医科大学附属第一医院收治的80例DMPA所致IUB患者,采用块状随机法将其分为氨甲环酸5 d治疗的治疗组和安慰剂5 d治疗的安慰剂组,每组各40例。随访观察4周,通过患者汇报的IUB信息表观察患者的7 d止血例数、28 d无出血时间及不良反应发生情况。 结果 安慰剂组失访1例,治疗组中33例(82.5%)受试者用药后7 d内止血;安慰剂组中10例(25.6%)受试者用药7 d内止血,差异有统计学意义(P < 0.05)。治疗组受试者28 d无出血时长为(20.73±4.07)d,安慰剂组为(11.90±5.78)d,差异有统计学意义(P < 0.05)。治疗组1例患者有轻微恶心。 结论 氨甲环酸治疗DMPA所致的IUB疗效显著,安全性好。
[关键词] 狄波-普维拉;氨甲环酸;疗效;安全性
[中图分类号] R711 [文献标识码] A [文章编号] 1673-7210(2017)05(c)-0121-03
[Abstract] Objective To explore the efficacy and safety of Tranexamic Acid in treating irregular uterine bleeding secondary to Depot-medroxyprogesterone acetat. Methods From December 2015 to December 2016, in First Affiliated Hospital of Chinese Medical Sciences University, 80 patients with irregular uterine bleeding secondary to Depot-medroxyprogesterone acetat treatment were recruited. According to random number table, they were divided into treatment group and placebo group with 40 cases in each group, and they were treated with Tranexamic Acid and placebo respectively. All patients were followed up for 4 weeks ......
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