张禹 冯园 郭大志

    [摘要] 脑白质疏松是指脑室周围或皮质下区脑白质在CT或者核磁上的一些非特异性表现。目前对于脑白质疏松的研究集中于其危险因素、临床表现、治疗等各个方面。多数研究表明脑白质疏松主要与低灌注造成白质区慢性缺血有关，也有研究认为脑白质疏松与人体某些基因和蛋白的改变关系密切，本文对脑白质疏松的基因组学和蛋白组学的最新研究进行综述。

    [关键词] 脑白质疏松；基因组学；蛋白组学；炎症因子

    [中图分类号] R742 [文献标识码] A [文章编号] 1673-7210(2017)08(a)-0055-04

    [Abstract] Leukoaraiosis is a descriptive term for rarefaction of the white matter， showing up as nonspecific changes in the periventricular and sub-cortex white matter frequently seen on CT and MRI. Currently researches focus on its risk factors， clinical manifestations， treatment， and so on. Most studies have shown that leukoaraiosis is caused by low perfusion of white matter area related to chronic ischemia. Studies also demonstrate the relationship between leukoaraiosis and certain changesof human genes and protein. In this paper， the newest genomics and proteomics researches of leukoaraiosis are reviewed.

    [Key words] Leukoaraiosis； Genomics； Proteomics； Inflammatory factor

    脑白质疏松症(LA)是一个影像学术语，最早于1987年由Steingart等[1]提出，用于描述脑室周围及半卵圆中心区脑白质在CT的弥漫性低密度影或核磁T2加权像的高信号表现，常两侧对称，病理表现为少突胶质细胞损伤、髓鞘脱失及星形胶质细胞增生等[2] ......