独家能+刘聪+郝旭亮+倪艳++许雯雯+季海霞

    [摘要] 失眠是指无法入睡或无法保持睡眠状态而导致次日白天社会功能严重下降的疾病。目前主要认为生理性失眠是由脑部中枢的γ-氨基丁酸(GABA)能神经元系统功能低下、应激中枢系统的下丘脑-垂体-肾上腺轴(HPA轴)功能亢进、褪黑素(MT)分泌水平下降及细胞因子等分泌失调造成的，以及一些特异性神经递质不同程度的表达，使中枢神经系统紊乱导致失眠的发生。本文从上述几个方面对生理性失眠的发病机理进行综述总结，为治疗失眠提供新的思路。

    [关键词] 生理性失眠；下丘脑-垂体-肾上腺轴；神经递质；发病机制

    [中图分类号] R749 [文献标识码] A [文章编号] 1673-7210(2017)10(b)-0037-04

    Research progress on pathogenesis of physiological insomnia

    DU Jianeng1 LIU Cong2 HAO Xuliang2 NI Yan2 XU Wenwen2 JI Haixia2

    1.Graduate School， Shanxi University of Chinese Medicine， Shanxi Province， Taiyuan 030619， China； 2.Shanxi Institute of Traditional Chinese Medicine， Shanxi Province， Taiyuan 030045， China

    [Abstract] Insomnia refers to the inability to fall or stay asleep leading to a serious decline in social function during the next day. At present， physiological insomnia was mainly caused by brain gamma aminobutyric acid (GABA) neurons system dysfunction， hyperactivity of hypothalamic pituitary adrenal axis (HPA axis)， melatonin (MT) secretion decline， cytokines secretion disorders and different degree expression of some specific neurotransmitters. In result of central nervous system dysfunction which leading to the occurrence of insomnia. This article summarized the pathogenesis of physiological insomnia the aspect above ......