赵雪煜 钱亚云

    [摘要] 恶性肿瘤是导致人类死亡的重要因素之一。恶性肿瘤的发生与某特定基因的异常表达密切相关。microRNA-125b(miR-125b)是一个非编码的小RNA分子，它在不同的生物学变化中均有举足轻重的地位。越来越多的研究显示对某些特定恶性肿瘤的诊断，miR-125b或许能作为其先进的生物标志，并且可能成为其医学治疗的潜在新靶点。根据miR-125b与肿瘤之间关系的最新研究成果，综述其在细胞增殖、耐药、侵袭转移及凋亡等多个方面对肿瘤的发生发展产生的具体影响。

    [关键词] microRNA-125b；肿瘤；增殖；凋亡；转移

    [中图分类号] R73 [文献标识码] A [文章编号] 1673-7210(2017)12(a)-0025-04

    [Abstract] Malignancy is one of the important factors leading to human death. The occurrence of malignant tumors is closely related to the abnormal expression of a particular gene. MicroRNA-125b (miR-125b) is a non-coding small RNA molecule that plays a pivotal role in different biological changes. More and more studies have shown that miR-125b may be an advanced biomarker for the diagnosis of certain specific malignancies and may be a potential new target for its medical treatment. According to the latest research results of the relationship between miR-125b and tumor， it is reviewed in the aspects of cell proliferation， apoptosis， invasion and metastasis and drug resistance.

    [Key words] microRNA-125b； Carcinoma； Proliferation； Apoptosis； Metastasis ......