黄书岚+刘宇航+王辉

    [摘要] 多形性胶质母细胞瘤(GBM)是最致命的一种异质性脑肿瘤，GBM患者存活时间为8～15个月。GBM由复杂的信号通路驱动，对于GBM的治疗一直被认为是最具挑战性的，GBM的标准治疗包括手术、放射治疗、化疗和联合治疗。本文综述了GBM的肿瘤间和肿瘤内异质性、最新的化疗药物及作用机制，重点介绍了一些天然合成和新型抗胶质瘤药物，也是当今研究人员的主要研究热点。

    [关键词] 多形性胶质母细胞瘤；异质性；联合治疗；化疗药物

    [中图分类号] R739.41 [文献标识码] A [文章编号] 1673-7210(2017)12(b)-0029-04

    [Abstract] Glioblastoma multiforme (GBM) is the most deadly type of heterogeneous brain tumor. The survival time of patients with pleomorphic glioblastoma is 8 to 15 months. GBM is driven by complex signaling pathways， the treatment of which has always been considered as the most challenging， the standard treatment for GBM includes surgery， radiation therapy， chemotherapy， and combination therapy. In this paper， the tumor interneoplasms of GBM and its heterogeneity and the latest chemotherapy drugs and mechanism are reviewed， this paper focuses on some natural synthesis and new anti-glioma drugs， which are also the main research focus of researchers today.

    [Key words] Glioblastoma multiforme； Heterogeneity； Combined therapy； Chemotherapeutic drugs

    多形性胶质母细胞瘤(GBM)是大脑中最具破坏性的肿瘤 ......