夏煜琦+程帆+袁润

    [摘要] 骨桥蛋白(OPN)为泌尿系结石基质主要有机成分之一，在肾结石患者及动物模型肾组织内含量明显增高。在肾结石形成各阶段包括晶体黏附、氧化应激、细胞凋亡等过程中扮演关键角色。OPN大量表达将导致晶体沉积，结石形成，最终造成肾脏细胞损伤。抗OPN抗体、抗氧化物及凋亡通路抑制剂能显著减轻OPN介导的结石形成。本综述旨在讨论近年来骨桥蛋白在肾结石形成机制中的新进展以及针对OPN的新的结石预防治疗靶点。

    [关键词] 骨桥蛋白；晶体黏附；氧化应激；细胞凋亡；肾结石

    [中图分类号] R692.4 [文献标识码] A [文章编号] 1673-7210(2018)01(a)-0045-04

    [Abstract] OPN is one of the main components of the organic phase of stone， which is highly expressed in the renal tissue of the kidney stones patients and animal stone models， and plays an important role in the process of crystal aggregation and adhesion， oxidative stress of renal tubular epithelial cells and apoptosis. A large amount of OPN expression will lead to crystal deposition， stone formation， resulting in kidney cell damage. OPN antibodies， antioxidants and apoptotic pathway inhibitors can significantly reduce OPN mediated stone formation. This review aims to discuss recent advances of the role of osteopontin in the formation of kidney stones and the new stone prevention and treatment target for OPN.

    [Key words] Osteopontin； Crystal adhesion； Oxidative stress； Apoptosis； Kidney stone ......