梁荣珍 王太成

    [摘要] 目的 探讨生长分化因子-15(GDF-15)基因rs1058587多态性与急性心肌梗死(AMI)的关系。 方法 选取2016年3月～2017年1月海南医学院第二附属医院心血管内科确诊AMI患者120例为AMI组，同期选取健康对象120例为健康组。采用聚合酶链反应PCR技术检测两组的GDF-15基因rs1058587位点基因型、等位基因频率，并探讨其与患者并发AMI的关系。 结果 AMI组的GDF-15基因rs1058587位点的CC、CG、GG基因型与健康组比较，差异有统计学意义(P < 0.05)；AMI组的GDF-15基因rs1058587位点等位基因G频率显著高于健康组(P < 0.05)；采用多因素Logistic回归分析结果显示：高密度脂蛋白胆固醇降低、低密度脂蛋白胆固醇升高、血清脂蛋白(a)升高、尿微量白蛋升高、GDF-15基因rs1058587位点的等位基因G是并发AMI的独立危险因素(P < 0.05)。 结论 GDF-15基因rs1058587多态性与人群发生AMI具有密切的关系。

    [关键词] 生长分化因子-15基因；rs1058587位点；急性心肌梗死

    [中图分类号] R541.4 [文献标识码] A [文章编号] 1673-7210(2018)04(b)-0067-04

    [Abstract] Objective To investigate the relationship between rs1058587 polymorphism of GDF-15 gene and acute myocardial infarction (AMI). Methods From January 2016 to January 2017， 120 patients with AMI of Cardiovascular Medicine Department in the Second Affiliated Hospital of Hainan Medical University were selected as AMI group. In the same period， 120 healthy subjects were selected as health group. The two groups were used by polymerase chain reaction PCR GDF-15 gene rs1058587 locus genotypes， allele frequencies ......