王晓梅 王松芝 欧江华

    [摘要] 目的 探讨曲妥珠单抗联合多西他赛、环磷酰胺化疗方案(TC)治疗人类表皮生长因子受体2(HER-2)过度表达乳腺癌的效果和安全性。 方法 选取2015年10月～2016年10月于新疆医科大学附属肿瘤医院就诊的79例乳腺癌患者作为研究对象，采用随机数字表法分为研究组与对照组，其中研究组38例，对照组41例。对照组患者在乳腺癌根治术前采用TC联合化疗，研究组在对照组基础上采用曲妥珠单抗治疗。治疗18周后，比较两组患者的治疗效果、不良反應发生率，比较两组治疗前后HER-2蛋白、B7同源体(B7-H1)及白细胞介素-2(IL-2)表达情况。 结果 治疗后研究组的总有效率显著高于对照组(P 0.05)。 结论 曲妥珠单抗联合TC方案可有效降低HER-2过度表达乳腺癌患者的HER-2蛋白、B7-H1和IL-2表达含量，提高临床治疗效果，且不会增加用药风险。

    [关键词] 曲妥珠单抗；HER-2过度表达；乳腺癌

    [中图分类号] R734 [文献标识码] A [文章编号] 1673-7210(2018)04(b)-0104-04

    [Abstract] Objective To investigate the efficacy and safety of Trastuzumab combined with Docetaxel and Cyclophosphamide chemotherapy in the treatment of HER-2 overexpression breast cancer. Methods From October 2015 to October 2016， 79 cases of breast cancer patients in Cancer Hospital Affiliated to Xinjiang Medical University were selected. The patients were divided into the study group (38 cases) and the control group (41 cases) according to the random number table method. The control group was treated with TC combined chemotherapy before radical mastectomy. The study group was treated with Trastuzumab on the basis of control group. After 18 weeks of treatment ......