内质网应激相关活性氧及其机制
孙晶 王巍 田野 田振[摘要] 内质网(ER)是细胞内的一个精细的膜系统,交织分布于细胞质中,主要负责蛋白合成、修饰、加工及新生肽链的折叠、运输等。改变ER的氧化环境及其内Ca2+含量会导致内质网应激(ERS)诱导的活性氧(ROS)的产生。其中,蛋白质二硫键异构酶、内质网氧化还原酶、谷胱甘肽/谷胱甘肽脱水酶、NADPH氧化酶4、细胞色素P450酶、Ca2+及线粒体呼吸链蛋白发挥着重要的作用。本文回顾了持续的ERS和蛋白质错误折叠引发的ROS级联及其相关机制。
[关键词] 内质网应激;活性氧;机制
[中图分类号] R363 [文献标识码] A [文章编号] 1673-7210(2018)06(a)-0042-04
[Abstract] Endoplasmic reticulum(ER) is the major site of calcium storage and protein folding. Alterations in the oxidative environment of ER and also intra-ER Ca2+ can cause the production of ERS-induced ROS. PDI, ERO-1, GSH, Nox4, CYP, Ca2+ and mitochondrial electron transport chain proteins play crucial roles in ERS-induced production of ROS. Here, persistent ERS and protein misfolding-initiated ROS cascades and their related mechanisms will be reviewed.
[Key words] Endoplasmic reticulum stress; Reactive oxygen species; Mechanism
内质网(endoplasmic reticulum ......
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