张国领 张林 刘桂萍

    [摘要] 同型半胱氨酸(Hcy)的代谢平衡受叶酸、B族维生素水平影响，叶酸缺乏、B族维生素不足、代谢酶基因突变是Hcy升高的主要原因。高同型半胱氨酸血症(HHcy)可导致心脑血管疾病、神经系统疾病、糖尿病、不良妊娠结局、慢性肾脏疾病、骨质疏松症等多种疾病，积极降低Hcy水平可以带来相关疾病风险的获益，合理补充叶酸、B族维生素是控制Hcy水平、预防和治疗相关疾病的有效措施。本文就HHcy的临床研究进展进行综述，以期为相关疾病的预防和治疗提供有益参考。

    [关键词] 同型半胱氨酸；高同型半胱氨酸血症；H型高血压；卒中；叶酸；B族维生素

    [中图分类号] R743.3 [文献标识码] A [文章编号] 1673-7210(2018)07(b)-0029-04

    [Abstract] The metabolic balance of homocysteine (Hcy) is affected by folic acid and B vitamins. The main reason for the increase of homocysteine is folate deficiency， deficiency of B vitamins and gene mutation of metabolic enzyme. Hyperhomocysteinemia (HHcy) can lead to a variety of diseases such as cardiovascular and cerebrovascular diseases， nervous system diseases， diabetes， adverse pregnancy outcomes， chronic renal diseases， osteoporosis and other diseases. The positive reduction of Hcy levels can benefit the risk of related diseases. The rational supplement of folic acid and B vitamins is an effective measure to control Hcy level and prevent and treat related diseases. This article reviews the clinical research progress of HHcy in order to provide useful reference for the prevention and treatment of related diseases. ......