胡莹莹 汪锡金

    [摘要] 帕金森病是一种慢性进行性的神经变性疾病，主要临床表现包括运动迟缓、肌强直、静止性震颤和姿势平衡障碍等运动症状及嗅觉减退、睡眠障碍、认知障碍、情绪障碍等非运动症状。褪黑素是一种主要由松果体合成的激素，具有调节昼夜节律、清除自由基、抗氧化、抗炎症、神经保护等多种作用。当机体褪黑素分泌节律紊乱时易发生多种神经变性疾病，如阿尔茨海默病、帕金森病。帕金森病与脑内褪黑素含量及受体的表达受损有关。外源性褪黑素能改善帕金森病的运动症状，同时对睡眠障碍、认知障碍、焦虑和抑郁等也显示出现一定的作用。本文概括了褪黑素能系统在帕金森病发病和治疗中的潜在作用。

    [关键词] 帕金森病；褪黑素；生物节律；运动症状；非运动症状；发病机制；神经保护作用

    [中图分类号] R742.5 [文献标识码] A [文章编号] 1673-7210(2018)07(c)-0023-04

    Study advance in the relationship between Parkinson′s disease and melatonin

    HU Yingying WANG Xijin

    Department of Neurology， Xinhua Hospital Affiliated to Shanghai Jiao Tong University Medical College， Shanghai 200092， China

    [Abstract] Parkinson′s disease is a chronic progressive neurodegenerative disease. The main clinical manifestations include motor syptoms such as bradykinesia， tremor， rigidity， and postural instability， as well as non-motor symptoms， such as impaired olfaction， sleep disorder， cognitive impairment， and emotional disorder. Melatonin is a hormone synthesized mainly by the pineal gland， regulating the circadian rhythm. Besides it acts as a free-radical scavenger ......