孙甲甲 涂悦 刘洋

    [摘要] 目的 比较经背部入路和经腹部入路构建肾血管性高血压大鼠模型的优缺点。 方法 将50只雌性SD大鼠按随机数字表法分为对照组(n = 10)、腹部入路组(n = 20)和背部入路组(n = 20)。腹部入路组沿腹正中线取约2.5 cm纵行切口，背部入路组经双侧脊柱旁肾脏所在处取约1.5 cm纵行切口，两组大鼠均结扎双侧肾动脉后支，缝合后自由饮食饲养。比较两组血压水平的变化、手术时长、伤口是否被啃食、术后感染率和死亡率。结果 腹部入路组及背部入路组大鼠术后3个月时血压均显著高于对照组(P 0.05)。 结论 两种入路构建肾血管性高血压大鼠模型各有特点，且术后的护理至关重要，需根据实际情况进行选择。

    [关键词] 肾血管性高血压；肾动脉；大鼠模型

    [中图分类号] R615 [文献标识码] A [文章编号] 1673-7210(2018)10(b)-0013-04

    [Abstract] Objective To compare the advantages and disadvantages of back approach and abdominal approach of establishing renovascular hypertension rat models. Methods According to random number table method， 50 female SD rats were divided into control group (n = 10)， abdominal approach group (n = 20) and back approach group (n = 20). Abdominal approach group was made an incision for about 2.5 cm along the abdominal medialline， back approach group was made two longitudinal incisions for about 1.5 cm along the bilateral paravertebral line where kidney located， both groups underwent ligation of posterior branches of bilateral renal arteries， with free diet after suture. The blood pressure ......