郑修广 张作文

    [摘要] 目的 探討不同剂量阿托伐他汀在治疗合并颈动脉不稳定斑块的高龄骨折患者围术期缺血性脑卒中中的临床效果及对应激指标、颈动脉斑块稳定性的影响。 方法 选取重庆市江津区中心医院2015年1月～2017年4月收治的围术期出现脑卒中的老年骨折患者76例，按照随机数字表法分为观察组和对照组，每组各38例，对照组予阿托伐他汀10 mg/d口服，观察组予阿托伐他汀20 mg/d口服，连续治疗6个月，观察两组患者临床疗效、应激反应指标水平及颈动脉斑块稳定性。 结果 治疗后观察组临床总有效率高于对照组，差异有统计学意义(P 0.05)。 结论 较大剂量的阿托伐他汀治疗合并颈动脉不稳定斑块的高龄骨折患者围术期缺血性脑卒中的效果满意，能够有效减轻患者氧化应激损伤，减少斑块面积，安全可靠。

    [关键词] 阿托伐他汀；高龄骨折；颈动脉斑块；缺血性卒中；氧化应激

    [中图分类号] R453 [文献标识码] A [文章编号] 1673-7210(2018)10(b)-0062-04

    [Abstract] Objective To investigate the effects of different dose of Atorvastatin on elderly patients with unstable carotid plaques complicated ischemic stroke in perioperative period， and the effects on stress and carotid plaque stability. Methods Seventy-six elderly patients with fractures admitted to Jiangjin District Central Hospital in Chongqing City from January 2015 to April 2017 were selected and they were divided into observation group and control group according to the random number table method， with 38 cases in each group. The control group was given Atorvastatin 10 mg/d oral and the observation group was given Atorvastatin 20 mg/d oral. The treating course was 6 months. The clinical efficacy ......