靳雯臻 谭晓川 文瑾 宋辉 张宇佳 郑稳生

    [摘要] 肝纤维化是严重威胁人类健康的慢性疾病。由于药物递送缺乏靶向性，肝纤维化治疗效果有限且常伴随着副作用的发生。为提高肝纤维化治疗效果，使用纳米载体达到靶向递送的研究越来越广泛。本文从靶向目标及载体种类方面综述了近年来靶向肝星状细胞治疗肝纤维化的纳米递送载体的研究进展，提供了肝纤维化靶向治疗的新思路，为实现高效治疗肝纤维化提供理论参考。

    [关键词] 肝纤维化;肝星状细胞;纳米载体;靶向递送

    [中图分类号] R512.62? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)03(c)-0034-04

    [Abstract] Hepatic fibrosis， a chronic disease， proposes a serious threat to human health. The low efficiency and occurrence of side effects are often contributed by the lack of liver specificity. In order to improve the therapeutic effect of liver fibrosis，research about the use of nanocarriers to achieve targeted delivery has become more and more extensive. This review summarizes the nano-delivery carriers targeting hepatic stellate cells that have been applied in the treatment of liver fibrosis in recent years from the type of carriers and target receptors，which offer a new idea to treat liver fibrosis and serve as the basis of designing safe and effective drug delivery systems for liber fibrosis.

    [Key words] Hepatic fibrosis; Hepatic stellate cells; Nanocarrier; Target delivery ......