刘波 王嘉麟 陈师林 石静纹 雷彬 王一帆 李红培

    [摘要] 小胶质细胞是中枢神经系统的主要免疫细胞，其介导的炎性反应在缺血缺氧性脑损伤中起着重要的作用。缺血性卒中是脑血管病的常见类型，现有的治疗手段不能获得满意的临床疗效，因此研究小胶质细胞的作用机制对缺血性卒中的治疗具有重要意义。本文就近年来国内外关于小胶质细胞活化及其对缺血缺氧性脑损伤的作用、相关药物治疗等研究展开综述，为缺血性卒中的治疗提供新思路。

    [关键词] 小胶质细胞;缺血缺氧性脑损伤;炎性反应;药物治疗

    [中图分类号] R743? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)03(c)-0038-05

    [Abstract] Microglia cells is the main immune cells in the central nervous system， which induced inflammatory response plays an important role in ischemic-hypoxic brain injury. Ischemic stroke is a common type of cerebrovascular disease， and the existing treatment methods cannot achieve satisfactory clinical efficacy. Therefore， the study on the mechanism of action of microglia cells is of great significance for the treatment of ischemic stroke. In this paper， recent studies on microglia activation and its effect on ischemic and hypoxic brain injury and related drug therapy at home and abroad were reviewed， providing new ideas for the treatment of ischemic stroke.

    [Key words] Microglial cells; Hypoxic-ischemic brain damage; Inflammatory response; Pharmaceutical drug ......