王立涛 连兴基 谭宁

    [摘要] 急性肾损伤(AKI)是一种以肾功能迅速下降、高死亡率为特征的常见严重疾病。然而，AKI的分子机制尚未明确，且缺乏有效的治疗方法。非编码RNA(ncRNAs)通过调控炎性反应、细胞程序性死亡、修复阶段的细胞周期等机制参与AKI发生的病理生理过程。因此，多种ncRNAs不仅被视为AKI的新型生物标志物，而且有望成为潜在的治疗靶点。本文综述了ncRNAs在AKI中的變化、功能及潜在治疗作用。

    [关键词] 非编码RNA；急性肾损伤；生物标志物；研究进展

    [中图分类号] R692 [文献标识码] A [文章编号] 1673-7210(2019)05(a)-0038-04

    Research progress on the relationship between non-coding RNA and acute kidney injury

    WANG Litao1，2 LIAN Xingji3 TAN Ning2 LIU Yuanhui2

    1.School of Medicine， South China University of Technology， Guangdong Province， Guangzhou 510006， China； 2.Department of Cardiology， Guangdong Cardiovascular Institute， Guangdong General Hospital， Guangdong Academy of Medical Sciences， Guangdong Province， Guangzhou 510100， China； 3.Department of Nephrology， Guangdong General Hospital， Guangdong Academy of Medical Sciences， Guangdong Province， Guangzhou 510100， China

    [Abstract] Acute kidney injury (AKI) is a common serious disease characterized by rapid decline in renal function and high mortality. However， the molecular mechanism of AKI is still unclear and there is no effective treatment. Non-coding RNA (ncRNAs) participate in the pathophysiological process of AKI by regulating inflammatory response ......