MFN2调控线粒体动态变化的研究进展
溶酶体,泛素,内质网
林晓莹 黄浩峰 陈浩[摘要] 线粒体通过自噬清除受损或多余线粒体以维持线粒体稳态。线粒体分裂融合是线粒体自噬的基础,线粒体融合蛋白-2(MFN2)参与调节线粒体分裂融合。MFN2突变会引起线粒体功能障碍,导致腓骨肌萎缩等神经退行性疾病。本文主要综述了近年来MFN2功能及其在线粒体自噬及神经退行性疾病领域所取得的研究进展,旨在为相关领域进一步的研究提供参考。
[关键词] 线粒体融合蛋白-2;线粒体;线粒体自噬;神经退行性疾病
[中图分类号] R363 [文献标识码] A [文章编号] 1673-7210(2019)05(a)-0042-04
Advances in the regulation of mitochondrial dynamic Changes by MFN2
LIN Xiaoying1 HUANG Haofeng1 CHEN Hao2 LI Shupeng3 ZHAO Bin4 ZHONG Wangtao5 FENG Du1
1.Guangdong Medical University, Guangdong Province, Zhanjiang 524000, China; 2.Department of Neurology, the First Afiliated Hospital of Hainan Medical University, Hainan Province, Haikou 570100, China; 3.Department of Neurology, Zengcheng District People′s Hospital, Guangdong Province, Guangzhou 511300, China; 4.Guangdong Key Laboratory of Age-related Cardiac-Cerebral Vascular Disease, Institute of Neurology, the Afiliated Hospital of Guangdong Medical University, Guangdong Province, Zhanjiang 524000, China; 5.Department of Neurology, the Afiliated Hospital of Guangdong Medical University, Guangdong Province, Zhanjiang 524000, China ......
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