李劲频 徐宏炎 莫雪安

    [摘要] 重症肌无力(MG)是一种累及神经肌肉接头的自身免疫性疾病，以骨骼肌的病态疲劳为主要特点，其发病与胸腺病变如胸腺瘤、胸腺肥大、淋巴滤泡增生及胸腺萎缩密切相关。MG的治疗包括应用胆碱酯酶抑制剂、免疫抑制剂、免疫球蛋白、血浆置换及胸腺切除术，胸腺切除术治疗合并胸腺瘤的MG患者效果确切。近年来有学者报道可应用胸腺切除术治疗非胸腺瘤MG患者，但其治疗价值目前还存在争议。本文就胸腺切除术治疗非胸腺瘤MG的研究进展进行综述。

    [关键词] 重症肌无力;胸腺;胸腺瘤;胸腺切除术

    [中图分类号] R746.1? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2019)06(a)-0054-03

    Research progress of thymectomy in the treatment of non-thymomatous myasthenia gravis

    LI Jinpin? ?XU Hongyan? ?MO Xuean▲

    Department of Neurology， the First Affiliated Hospital of Guangxi Medical University， Guangxi Zhuang Autonomous Region， Nanning? ?530021， China

    [Abstract] Myasthenia gravis (MG) is an autoimmune disease involving neuromuscular junction， taking pathological fatigue of skeletal muscle as main characteristics， its pathogenesis is closely related to thymic lesion， such as thymoma， megalothymus， lymphoblastic follicular hyperplasia， and thymic atrophy. The treatment of MG includes application of cholinesterase inhibitors， immunosuppressor， immune globulin， plasmapheresis and thymectomy， the effect of thymectomy in the treatment of MG patients combined with thymoma is exact. In recent years ......