ApoE基因敲除小鼠疾病模型的研究进展
宋珂 侯彦宏 杨会 白云绮 李慧 聂波[摘要] 载脂蛋白E(ApoE)是一种有明显基因多态性、多功能蛋白,与脂蛋白的代谢有密切联系,其缺失和变异都会引起体内代谢失常及功能紊乱,甚至引起一系列疾病和并发症。近年来,ApoE-/-小鼠主要应用于动脉粥样硬化、糖尿病、神经退化性疾病、肾脏病等。为了更好地研究ApoE在各疾病模型中的应用机制,为临床疾病治疗提供更加有力的依据,本文总结了人类ApoE基因型与ApoE蛋白相关的几种疾病的发生机制,并对体外研究疾病发展过程的动物模型进行了综述。
[关键词] 载脂蛋白E;基因敲除;动物模型;研究进展
[中图分类号] R332 ? ? ? ? ?[文献标识码] A ? ? ? ? ?[文章编号] 1673-7210(2019)06(c)-0042-04
Advances in research on disease model of ApoE knockout mice
SONG Ke1 ? HOU Yanhong2 ? YANG Hui3 ? BAI Yunqi1 ? LI Hui3 ? NIE Bo1
1.Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing Key Laboratory, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing ? 100700, China; 2.Research Center for Chinese Medicine Development, China Academy of Chinese Medical Sciences, Beijing ? 100700, China; 3.School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing ? 100029, China
[Abstract] Apolipoprotein E (ApoE) is a kind of gene polymorphism and multifunctional protein, which is closely related to the metabolism of lipoprotein. Its deletions and mutations can cause metabolic disorders and dysfunction in the body ......
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