吕朦 刘秀香

    [摘要] 随着肠外营养在新生儿中的广泛使用，肠外营养相关性胆汁淤积(PNAC)也成为新生儿特别是早产儿常见的并发症之一。该病常引起患儿肝细胞脂肪变性及胆汁淤积，进而形成胆汁性肝硬化，严重时可引起肝衰竭甚至死亡。因此该病应引起新生儿医师的高度重视。由于PNAC的发病机制尚不明确并存在许多争议，本文通过研究并总结大量近年来关于PNAC的文献，发现PNAC多与早产及低出生体重、长时间禁食、感染、肠外营养应用时间及营养比例失调、遗传等因素有关，本文将对其已知的发病机制、诊断、治疗及新的研究进展进行综述。

    [关键词] 新生儿;早产儿;肠外营养相关性胆汁淤积;肠外营养

    [中图分类号] R722.1 ? ? ? ? ?[文献标识码] A ? ? ? ? ?[文章编号] 1673-7210(2019)12(c)-0046-04

    Research progress on parenteral nutrition associated cholestasis in neonates

    LYU Meng1 ? LIU Xiuxiang1，2

    1.Department of Neonatology， the Affiliated Hospital of Binzhou Medical University， Shandong Province， Binzhou 256603， China; 2.Neonatal Intensive Care Unit， Qingdao Women and Children′s Hospital， Shandong Province， Qingdao ? 266034， China

    [Abstract] With the widespread use of parenteral nutrition in newborns， parenteral nutrition associated cholestasis (PNAC) has become one of the common complications in neonates， especially preterm infants. The disease often causes hepatocyte steatosis and cholestasis of the child， leads to biliary cirrhosis， which can cause liver failure and even death. Therefore ......