徐杨 熊英琼

    [摘要] 基质金属蛋白酶9(MMP-9)通过促进炎性反应加重缺血性脑卒中(脑梗死)的发展，对疾病预后不利。血管内皮生长因子(VEGF)有利于缺血灶和半暗带血管侧支循环的建立，在脑梗死损伤修复中相对有利。但是MMP-9和VEGF又有着复杂的相互作用，疾病发生时二者浓度的变化可能协同加剧缺血脑组织的损害。本文就近年来对MMP-9和VEGF在脑梗死发展过程中的作用及二者的相互影响做一综述，提出在脑梗死发生后及时降低MMP-9浓度并适时促进VEGF含量可能对预后更有利。

    [关键词] 基质金属蛋白酶9;血管内皮生长因子;脑梗死

    [中图分类号] R743.3? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)01(c)-0041-04

    Effect of matrix metalloproteinase-9 and vascular endothelial growth factor on ischemic stroke

    XU Yang XIONG Yingqiong

    1.Graduate School， Jiangxi University of Traditional Chinese Medicine， Jiangxi Province， Nanchang? ?330000， China; 2.Department of Neurology， Jiangxi Provincial People′s Hospital， Jiangxi Province， Nanchang? ?330006， China

    [Abstract] Matrix metalloproteinase 9 (MMP-9) can aggravate the development of ischemic stroke (brain infarction) disease by promoting inflammatory response， which is detrimental to the prognosis of the disease. Vascular endothelial growth factor (VEGF) is beneficial to the establishment of ischemic and penumbra collateral circulation， and plays a relatively beneficial role in the repair of brain infarction injury. However ......