史有阳 杨瑞 韩向晖 孙霃平 刘胜

    [摘要] 阴阳理论是中医学理论的基石。中医学认为，人体生理功能的维持基于阴阳之间的动态平衡，疾病的发生是阴阳失衡的结果。线粒体是细胞能量代谢的中心，大多数细胞中线粒体是高度动态的，通过不断地融合、分裂来维持细胞正常的生理功能，其间存在着对立制约、互根互用、消长平衡的关系，这与中医阴阳理论相得益彰。线粒体融合、分裂不仅在维持线粒体自身结构功能方面扮演着重要角色，还与心血管、神经、消化系统及肿瘤等疾病密切相关。本文试从调整“阴阳平衡”的角度论述中医药对相关疾病线粒体融合分裂的作用及机制。

    [关键词] 阴阳平衡;线粒体;融合-分裂;疾病

    [中图分类号] R243? [文献标识码] A? [文章编号] 1673-7210(2020)01(c)-0132-04

    The effect of traditional Chinese medicine on mitochondrial fusion and fission in related diseases based on the theory of “yin and yang balance”

    SHI Youyang1，2? YANG Rui1，2? HAN Xianghui2? SUN Chenping1? LIU Sheng1，2

    1.Breast Department of Integrated Chinese and Western Medicine， Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine， Shanghai? 200032， China; 2.Institute of Traditional Chinese Medicine Surgery， Shanghai University of Traditional Chinese Medicine， Shanghai? 200032， China

    [Abstract] The theory of yin and yang is the cornerstone of traditional Chinese medicine theory. Traditional Chinese medicine hold the view that the physiological function of the human body lies in the dynamic balance between yin and yang. The occurrence of diseases is the result of imbalance between yin and yang. Mitochondrion is the center of energy metabolism in the cell ......