刘海涛 葛伟

    [摘要] 阿尔茨海默病(AD)是老龄化社会面临的一种慢性进行性神经变性病，氧化应激损伤及有毒醛类物质蓄积在AD发病过程中起到重要作用。线粒体乙醛脱氢酶2(ALDH2)是一种醛类氧化还原酶，其活性与基因型相关，ALDH2无功能突变携带者患AD的风险更高。基础研究提示ALDH2可减少氧化应激产生的4-羟基壬烯醛等醛类物质在重要脏器尤其是脑组织的沉积，从而减轻神经细胞的氧化应激损伤。本文拟综述ALDH2在AD中的作用研究，为疾病预防和控制提供新的思路。

    [关键词] 乙醛脱氢酶2;阿尔茨海默病;氧化应激;4-羟基壬烯醛

    [中图分类号] R742? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)02(a)-0036-04

    [Abstract] Alzheimer′s disease (AD) is a chronic， progressive neurodegenerative disease， and oxidative stress injury and toxic aldehydes deposition play an important role in AD pathology. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is an aldehyde oxidation-reduction enzyme. ALDH2 activity is determined by its genotype. Carriers of ALDH2 mutation have a higher risk of suffering AD. Basic studies suggest that ALDH2 can reduce the deposition of 4-HNE produced by oxidative stress in important organs， especially brain tissues， thereby reducing the oxidative stress injury of neuronal cells. This article will review the research progress of ALDH2 in AD， and provide novel insights for disease prevention and control.

    [Key words] Aldehyde dehydrogenase 2; Alzheimer′s disease; Oxidative stress; 4-HNE ......