丁欢 吴承杰 潘娅岚 徐桂华 杨敏 史旭芹 王庆

    [摘要] 骨髓抑制是化疗后的常见毒副作用，主要与损伤造血干细胞与造血微环境有关。黄芪、当归具有补益气血、扶正补虚的功效，临床常用于改善骨髓抑制。药理研究发现，二者有效成分可通过促进造血细胞增殖、分化而改善化疗后的骨髓抑制，具体机制与多条通路有关，但尚未被阐明，影响进一步的临床应用与推广。本文针对黄芪及当归改善骨髓微环境相关分子机制做出归纳总结，以期为补气血中药改善骨髓抑制的分子机制研究拓展思路，为推广黄芪及当归改善骨髓抑制的临床应用奠定基础。

    [关键词] 黄芪;当归;造血干细胞;骨髓抑制;造血微环境

    [中图分类号] R273? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)02(b)-0023-04

    Advances in molecular mechanism of milkvetch root and Chinese angelica to improve myelosuppression after chemotherapy

    DING Huan1? ?WU Chengjie2? ?PAN Yalan1? ?XU Guihua1? ?YANG Min1? ?SHI Xuqin3? ?WANG Qing1

    1.College of Nursing， Nanjing University of Chinese Medicine， Jiangsu Province， Nanjing? ?210023， China; 2.the First School of Clinical Medicine， Nanjing University of Chinese Medicine， Jiangsu Province， Nanjing? ?210023， China; 3.College of Pharmacy， Nanjing University of Chinese Medicine， Jiangsu Province， Nanjing? ?210023， China

    [Abstract] Myelosuppression is a common toxic and side effect after chemotherapy， mainly related to injury of hematopoietic stem cells and hemopoietic microenvironment. Milkvetch root and Chinese angelica have the functions of benefiting qi and blood ......