蔡彬 周敏红 李春伟

    [摘要] 炎症性肠病(IBD)是一种病因尚未明确的肠道黏膜慢性非特异性炎症性疾病，包括克罗恩病和溃疡性结肠炎，其病因及发病机制尚未完全清楚，一般认为与环境、遗传、感染及免疫等多种因素有关。氨基酸是生物体内重要的营养物质，是促进肠道生长、维持肠道黏膜完整和屏障功能的必需物质，作为肠细胞的能量底物，是促进肠黏膜愈合的物质基础。大量研究证实IBD疾病过程中存在氨基酸代谢异常，包括谷氨酰胺、谷氨酸、精氨酸、色氨酸、半胱氨酸、甘氨酸等，并且补充上述氨基酸对IBD肠道损伤具有保护作用。其作用机制涉及刺激肠上皮细胞增殖，抑制氧化应激损伤，减少促炎细胞因子释放，增加上皮细胞迁移能力等。本文通过收集国内外相关文献，旨在探讨氨基酸在IBD治疗中的潜在价值。

    [关键词] 氨基酸;炎症性肠病;溃疡性结肠炎;克罗恩病

    [中图分类号] R574? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)03(c)-0037-04

    [Abstract] Inflammatory bowel disease (IBD) is a chronic non-specific inflammatory disease of the intestinal mucosa with unknown etiology， including crohn′s disease and ulcerative colitis. The etiology and pathogenesis are not completely clear， and it is generally believed to be related to environment， heredity， infection and immunity. Amino acids are important nutrients in living organisms， which are essential substances for promoting intestinal growth， maintaining intestinal mucosal integrity and barrier function. Amino acids are also energy substrates for intestinal cells and the material basis for wound healing of intestinal mucosa. A large number of studies have confirmed the abnormal amino acid metabolism in the course of IBD disease ......