徐坤勇 杜茂波 郭建忠

    [摘要] 柚皮苷是一种天然的黄酮类化合物，具有抑制甲状腺癌细胞增殖并诱导其凋亡、保护受损心肌等药理作用。柚皮苷常规制剂吸收差，生物利用度低，限制了柚皮苷的临床应用。研究显示，将柚皮苷制备成柚皮苷亲水凝胶骨架片、柚皮苷脂质体凝胶、柚皮苷-卵磷脂包合物、柚皮苷固体脂质纳米粒、柚皮苷纳米乳等可以提高生物利用度，增强缓释和靶向作用。因此，研制新剂型对扩大柚皮苷的临床应用具有重要意义。本文通过检索文献，对近年来出现的柚皮苷制剂进行综述，以期为柚皮苷制剂的进一步研究与开发提供参考。

    [关键词] 柚皮苷;制剂;给药途径;新剂型;研究进展

    [中图分类号] R283.6 ? ? ? ? ?[文献标识码] A ? ? ? ? ?[文章编号] 1673-7210(2020)06(a)-0058-04

    [Abstract] Naringin is a natural flavonoid compound， which has the pharmacological effects of inhibiting the proliferation of thyroid cancer cells and inducing their apoptosis， protecting the damaged myocardium， etc. The conventional preparation of naringin has poor absorption and low bioavailability， which limits the clinical application of naringin. Studies have showed that naringin is prepared into naringin hydrophilic gel matrix tablets， naringin liposome gel， naringin-lecithin inclusion complex， naringin solid lipid nanoparticles， naringin nanoemulsions can improve bioavailability and enhance sustained release and targeting. Therefore， the development of new dosage forms is of great significance for expanding the clinical application of naringin. This study reviews the naringin preparations in recent years through literature retrieval ......