解利红 王宝军

    [摘要] TAM受体是受体酪氨酸酶的亚家族，包括3个成员Tyro3、Axl和Mertk。其共同配体是生长停滞特异性基因6(Gas6)和蛋白S(ProS1)。TAM受体和配体广泛表达于哺乳动物免疫、血液、生殖、循环和神经等系统的多种细胞中，具有抑制细胞凋亡、促进细胞增殖和介导细胞黏附、迁移、吞噬凋亡细胞、参与免疫调节等多种生物学功能。TAM受体及其配体在自身免疫性疾病中扮演着重要的角色。

    [关键词] TAM受体;特异性基因6;蛋白S;TAM 信号通路;自身免疫性疾病

    [中图分类号] R34? ? ? ? ? [文献标识码] A? ? ? ? ? [文章编号] 1673-7210(2020)07(c)-0034-04

    Research progress of TAM receptors and its signaling pathways in immune regulation

    XIE Lihong1? ?WANG Baojun2▲

    1.Department of Neurology， Baotou Clinical Medical College， Inner Mongolia Medical University， Inner Mongolia Autonomous Region， Baotou? ?014040， China; 2.Department of Neurology， Center Hospital of Baotou， Inner Mongolia Autonomous Region， Baotou? ?014040， China

    [Abstract] TAM receptor is a subfamily of receptor tyrosinase， including three members Tyro3， Axl and Mertk. The common ligands of the TAM receptors are growth arrest specific gene 6 (Gas6) and S protein (ProS1). TAM receptors and ligands are widely expressed in mammalian immune， blood， reproductive， circulatory and nervous systems， and have many biological functions ......