张纯萍

    [摘要] 糖尿病以及并发症已成为威胁人类健康的主要疾病之一。芹菜素是广泛分布于各种蔬菜和水果中的天然黄酮类化合物，芹菜素具有抗氧化、抗炎、保护神经等作用，并从机制上肯定了其治疗糖尿病及其并发症的有效性。本文对芹菜素治疗糖尿病及其并发症的作用机制进行归纳总结，包括芹菜素可减少抗氧化应激、保护胰岛β细胞线粒体膜、增加胰岛素敏感性、激活过氧化物酶体增殖物激活受体-γ改善心肌梗死后血流动力学紊乱以及抑制胶原Ⅳ、纤连蛋白改善肾脏的纤维化，说明芹菜素具有多靶点、多途径、多层次等治疗优势，可用于治疗糖尿病及其并发症，改善预后，具有广阔的研究前景，为进一步开发芹菜素提供新的思路和依据。

    [关键词] 芹菜素;糖尿病;研究进展;作用机制

    [中图分类号] R587.1 ? ? ? ? ?[文献标识码] A ? ? ? ? ?[文章编号] 1673-7210(2020)08(b)-0034-03

    [Abstract] Diabetes mellitus and its complications have become one of the major diseases threatening human health. Apigenin is a natural flavonoid widely distributed in a variety of vegetables and fruits. Apigenin has antioxidant， anti-inflammatory and neuroprotective effects， and confirmed its effectiveness in the treatment of diabetes mellitus and its complications. This paper summarizes the mechanism of apigenin in the treatment of diabetes mellitus and its complications， including apigenin can reduce antioxidant stress， protect the mitochondrial membrane of pancreatic beta cells， increase insulin sensitivity， and activate peroxisome proliferator-activated receptor-γ (PPAR-γ) to improve hemodynamics disorder after myocardial infarction and inhibits collagen Ⅳ and fibronectin to improve renal fibrosis. These results indicate that apigenin has therapeutic and prognostic advantages in patients with diabetes mellitus and complications based on multi-target ......