PTTG、bFGF和VEGF在子宫内膜异位症中的表达及意义(2)
PTTG蛋白激活了bFGF蛋白和VEGF蛋白的表达，而bFGF与VEGF两者促进血管内皮细胞分裂，降解基底膜刺激内皮细胞向肿瘤组织内趋化运动，形成新生血管。而血管生成恰恰是实体瘤生成过程中的限速步骤。bFGF对诱导PTTG的表达有重要意义，而且在内分泌相关肿瘤内，bFGF及PTTG间有协同作用[2-4]。
本研究显示，bFGF、PTTG、VEGF在子宫内膜异位症中的阳性表达率高于正常子宫内膜组织，且在子宫内膜异位症组织中三者的表达呈正相关。PTTG的过度表达导致了处于G2期细胞的积累，加速了细胞周期的进程[5]。
检测异位内膜中的PTTG、bFGF、VEGF，有利于子宫内膜异位症的诊断及其生物学行为的判断。我们推测，采取下调或消除PTTG的表达的方法可为子宫内膜异位症的治疗开辟一条新的途径。
参考文献
1 Zhang X,Horwitz GA,Prezant TR,et al.Structure,expression,and function of human pituitary tumor-transforming gone(PTTG).Mol Endocrinol,1999,13:156-166.
2 HeaneyAP,Nelson V,Fernando M,et al.Transformingeventsinthyroid tumorigenesis andtheir association with follicular lesions.Chin Endocrinol Metab,2001,86:5025-5032.
3 Heaney AP,Horwitz GA,Wang Z,et al.Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growthfactor expression in prolactinomapathogensis.Nal Mel,1999,5:1317-1321.
4 Kakar SS.Molecular cloning,genomic organization,and identification of the promoter for the humanpituitary tumor transforming gene(PTTG).Gene,1999,240:317-324.
5 Sako A,Kitayama J,Yam aguchi H,et al.Vascular endothelial growth foctor synthesis is by human omentalm esothelial cells is augmented by fibrobliast growth factoi-2 Possible role of mesotheilial cell on the development of peritonealm etastasis.SurgRes,2003,115(1)：113., http://www.100md.com(吕晓霞 李 楠 张师前)
本研究显示，bFGF、PTTG、VEGF在子宫内膜异位症中的阳性表达率高于正常子宫内膜组织，且在子宫内膜异位症组织中三者的表达呈正相关。PTTG的过度表达导致了处于G2期细胞的积累，加速了细胞周期的进程[5]。
检测异位内膜中的PTTG、bFGF、VEGF，有利于子宫内膜异位症的诊断及其生物学行为的判断。我们推测，采取下调或消除PTTG的表达的方法可为子宫内膜异位症的治疗开辟一条新的途径。
参考文献
1 Zhang X,Horwitz GA,Prezant TR,et al.Structure,expression,and function of human pituitary tumor-transforming gone(PTTG).Mol Endocrinol,1999,13:156-166.
2 HeaneyAP,Nelson V,Fernando M,et al.Transformingeventsinthyroid tumorigenesis andtheir association with follicular lesions.Chin Endocrinol Metab,2001,86:5025-5032.
3 Heaney AP,Horwitz GA,Wang Z,et al.Early involvement of estrogen-induced pituitary tumor transforming gene and fibroblast growthfactor expression in prolactinomapathogensis.Nal Mel,1999,5:1317-1321.
4 Kakar SS.Molecular cloning,genomic organization,and identification of the promoter for the humanpituitary tumor transforming gene(PTTG).Gene,1999,240:317-324.
5 Sako A,Kitayama J,Yam aguchi H,et al.Vascular endothelial growth foctor synthesis is by human omentalm esothelial cells is augmented by fibrobliast growth factoi-2 Possible role of mesotheilial cell on the development of peritonealm etastasis.SurgRes,2003,115(1)：113., http://www.100md.com(吕晓霞 李 楠 张师前)