【摘要】 目的 探讨甲氨蝶呤(MTX)联合米非司酮治疗非破裂输卵管妊娠的效果。方法 随机选取32例非破裂型输卵管妊娠患者采用米非司酮300 mg一次顿服，MTX20 mg静脉滴注5 d。另选32例单用MTX的患者设为对照组。结果 MTX联合米非司酮治疗的成功率为87.5%，明显高于对照组。观察治疗期间病情变化，发现疗效与血β-hCG高低及有无心管搏动有关。结论 MTX联合米非司酮治疗非破裂型输卵管妊娠安全有效，适用于生命体征平稳、无剧烈腹痛、无心管搏动及血β-hCG<2000IU/l的非破裂型输卵管妊娠。

    【关键词】 输卵管妊娠：药物治疗；甲氨蝶呤；米非司酮。

    Report of combination use of MTX and mifepristone in treating 32 patients with unruptured tubal pregnancy Pu Ai Hospital of Wuhan,Wuhan 430023,China

    【Abstract】 Objective To investigate the effect of combining use of methotrexate and mifepristone on treating unruptured tubal pregnancy. Methods Treatment consisted of 300 mg of mifepristone administered orally one time and 20 mg of methotrexate injected intravenously consecutively for 5 days. The prvious cases who received only 20 mg methotrexate injected intravenously were selected as control group. Results The success rate of the combination group was 87.5% which was significantly higher than that of the control group.The effect of treatment was related to serum β-hCG levels and whether there was embryos with cardiac activity of not. Conclusion The treatment of unruptured tubal pregnancy with the combination of methotrexate and mifepristone is safe and effective.It is suitable for the unruptured tubal pregnancy with stable vital signs, but without acute abdominal pain or embryonic cardian activity and β-hCG<2000IU/L. ......