【摘要】 目的 研究在室温下葡萄糖氯化钠钾注射液(简称GNK)分别与甲硝唑注射液、替硝唑葡萄糖注射液配伍后的稳定性。方法 采用RP-HPLC法分别测定配伍后甲硝唑和替硝唑的含量变化，同时考察配伍溶液的外观、pH值和不溶性微粒的变化。结果 在室温下配伍溶液8 h内均无气体或沉淀产生，pH值、不溶性微粒和含量均无明显变化。结论 GNK与甲硝唑注射液、替硝唑葡萄糖注射液配伍后8 h稳定，在8 h内可安全应用于临床。

    【关键词】配伍稳定性；葡萄糖氯化钠钾注射液；甲硝唑；替硝唑

    Compatible stabilities of glucose and sodium chloride potassium chloride injection mixing with metronidazole and tinidazole for injection

    MA Ai-ling,CHEN Xiao-hui,WEI Jing-hai,et al.Department of Pharmaceutical Analysis,Shenyang Pharmaceutical University,Shenyang 110016,China

    【Abstract】 Objective To observe the stabilities of glucose and sodium chloride potassium injection(GNK)mixing with metronidazole and tinidazole at 25℃.Methods RP-HPLC was applied to determine the content changing of metronidazole and tinidazole in different time.The pH,quantity of non-soluble particulate and appearance of mixtures were also observed.ResultsIn room temperature the mixtures produced neither gas nor sediment.The pH,quantity of non-soluble particulate and content did not change within 8 hours.ConclusionThe mixtures of GNK mixing with metronidazole and tinidazole were stable in 8 hours. ......