【摘要】 目的 探讨尿路感染的病原菌及其耐药性变化趋势。方法 收集2004年6月至2007年12月清洁中段尿培养分离的病原菌并作细菌药敏及其耐药性分析。结果 共收集致病菌467株，革兰阴性杆菌348株，占74.52%；革兰阳性菌69株，占14.78%；真菌50株，占10.71%。革兰阴性杆菌以大肠埃希菌为主(50.01%)，革兰阳性菌以肠球菌和凝固酶阴性葡萄球菌为主，真菌以白色假丝酵母菌为主。3年间主要病原菌对常用抗菌药物的耐药率呈上升趋势。结论 我院尿路感染的病原菌仍以大肠埃希菌为主，但多重耐药菌的分离率呈上升趋势。

    【关键词】 尿路感染；病原菌；耐药性

    Pathogens and antibiotic resistance analysis in urinary tract infection

    XU Xin-wei,WANG Zhen,ZHAO Jun.Weifang People’s Hospital,Shandong Weifang 261041，China

    【Abstract】 Objective To investigate the bacterial distribution trend of drug resistance in uninary tract infection(UTI).Methods The antibiotic resistance of clinical isolates from urinary trcat infection from July,2004 to December,2007 was analyzed.Results Among 467 isolates,348 strains(74.52%)were Gram-negative bacilli,69(14.78%)were Gram-positive cocci and 50(10.71%)fungi.The majority of Gram-negative bacilli were Escherichia coli(50.01%)and the majority of fungi was Candida albicans,as for Gram-positive cocci,were Enterococcus faecalis and coagulase negative Staphylococcus.Drug resistance rate of common antibiotic against the majority of urinary pathogens showed an ascending trend.Conclusion Ecoli is still the primary urinary pathogen,but the antibiotic resistance of commonly encountered pathogens is on the rise. ......