【摘要】 目的 探讨儿童支气管哮喘 (简称哮喘) 发作期淋巴细胞免疫功能和白细胞介素-2(IL-2)、可溶性白介素2受体(sIL-2R)检测的临床意义。方法 应用流式细胞术和酶联免疫吸附试验(ELISA)方法对25例支气管哮喘患儿和21例支气管哮喘缓解期患儿以及 20例正常儿童外周血T细胞亚群及血清IL-2和sIL-2R水平进行测定。结果 支气管哮喘患儿发作期血清sIL-2R水平明显高于缓解期和对照组，缓解期sIL-2R水平仍高于对照组。IL-2水平明显低于缓解期和对照组。外周血总CD3⁺、CD4⁺、CD4⁺/CD8⁺细胞比值均降低，CD8⁺细胞增高。结论 动态监测IL-2和sIL-2R水平含量，观察T细胞亚群变化可以判断哮喘发作的程度、指导治疗和评估预后。

    【关键词】 支气管哮喘；T细胞亚群；IL-2

    The change and clinical significant of cellular immunity and interleukin in children with bronchial asthma

    TANG Shu-sheng,HUANG Xiao-yan.The hospital of Guangzhou Red Cross,Guangzhou 510220,China

    【Abstract】 Objective To investigate the clinical significance of relationship between cellular immunity and interleukin (IL-2、sIL-2R) in children with bronchial asthma . Methods T cell subset was assayed by flow cytometry in 25 children with NS in attack phase ......