米非司酮治疗绝经过渡期子宫肌瘤72例临床观察
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【摘要】 目的 探讨米非司酮在治疗绝经过渡期子宫肌瘤方面的疗效。方法 对已确诊为绝经过渡期子宫肌瘤的患者,每日口服米非司酮12.5 mg,连续6个月,观察治疗后子宫体积、内膜厚度,血清性激素水平,停药半年月经情况。结果 用药后子宫体积变小，血FSH、LH、P激素水平下降，临床症状改善或基本消失,子宫内膜厚度均表现为早卵泡期内膜。结论 米非司酮具有很强的非竞争性抗雌激素作用,阻碍增生的子宫内膜对生理雌激素的正常反应而使子宫内膜萎缩，出血减少。并减少子宫动脉血流量，使瘤体体积缩小，症状减轻。本研究在服用米非司酮对治疗绝经过渡期子宫肌瘤方面效果肯定,安全可行。
【关键词】绝经过渡期;子宫肌瘤;米非司酮;疗效
【Abstract】 Objective Searches begs for mifepristone in the treatment menopause transition-period the fibroid aspect curative effect.Methods Cases who hadbeen diagnosed for the menopause transition-period myoma of uterus patients,takes orally mifepristone 12.5 mg every day,continual 6 months,after observation treatment,the womb volume,internal membrane thickness,the blood serum sex hormone level,stopped the medicine half years after the situation.Results After the medication,the womb volume changes were small,blood FSH,LH,the P hormone level drops,the clinical symptoms improvement or basic vanishing,endometrium thickness displays for the early follicular phase internal membrane.Conclusion Mifepristone has the very strong non-competitive anti-estrogen function,its hindrance proliferation’s endometrium causes the endometrium to the physiological estrogen’s normal response to wither,the hemorrhage reduces.Causes in the myoma organization the female progestogen effect to reduce obviously,and reduces the arteria uterina blood stream quantity,the lump body volume reduces,the symptom reduces.This material is taking mifepristone to treat the menopause transition-period the myoma of uterus aspect effect to affirm,safe feasible. ......
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