等比重布比卡因对剖宫产术脊麻ED50与ED95的研究(1)
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【摘要】 目的 测定等比重布比卡因用于剖宫产术蛛网膜下腔阻滞麻醉的ED50及ED95。方法 40例拟行剖宫产术的产妇在蛛网膜下腔注射预设剂量的0.75%布比卡因。按序贯试验法设定布比卡因给药剂量，起始剂量为9 mg，剂量间隔为1.5 mg。用概率单位回归法计算ED50及ED95。结果 布比卡因的ED50为8.0 mg(95%置信区间为7.1～9.0 mg)，ED95为11.3 mg(95%置信区间为9.7～21.4 mg)。结论 剖宫产术腰硬联合麻醉需应用相对较大剂量等比重布比卡因才能提高麻醉成功率。
【关键词】 麻醉；脊椎；布比卡因；剂量效应关系；药物
ED50 and ED95 of intrathecal isobaric bupivacaine for caesarean section
XU Kang-qing, ZHANG Jin-jun, ZHANG Tao, et al. Department of Anesthesia, the First Affiliated Hospital, Sun Yat-sen University, Guangdong510080, China
【Abstract】 Objective To determine the ED50 and ED95 of intrathecal isobaric bupivacaine (with adjuvant opioids) for cesarean delivery. Methods 40 pregnant patients were enrolled to receive combined spinal and epidural anesthesia. Using a sequential technique, varying doses of 0.75% isobaric bupivacaine were administered. ED50 and ED95 were estimated from probit regression. Results The ED50 for isobaric bupivacaine was 8.0 mg, 95% CI 7.1 mg to 9.0 mg. Conclusion This study support the use of larger bupivacaine doses to ensure successful anesthesia. ......
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