中药新乐康与阿普唑仑治疗失眠对照研究
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【摘要】 目的 探讨中药新乐康治疗失眠的临床疗效及安全性。 方法 将53例失眠症患者随机分为中药组31例，对照组22例；中药组给予新乐康治疗，对照组给予阿普唑仑治疗，观察4周。于治疗前及治疗第2 周 、4周末采用睡眠状态问卷量表评定临床疗效，临床总体量表中对不良反应评分法评定。结果 治疗4周末，中药组显效率54.9%，对照组为59.1%(P>0.05)；SQ评分两组治疗2周末起均较治疗前有极显著性下降(P<0.01)，并随治疗时间的延续逐渐下降；同期两组间评分差异均无统计学意义(P>0.05)。中药组的不良反应明显低于阿普唑仑组。结论 新乐康治疗失眠疗效与阿普唑仑相当，不良反应明显少于阿普唑仑，安全性、依从性好。
【关键词】失眠; 新乐康; 阿普唑仑
Control observation of xinlekang pian and alprazolam in the treatment of insomnia
ZHANG Xiu-li , CUI yu-zhen, YANG Xiu-shuang.
Jiaozuo Psychiatric Hospital, Henan 454000, China
【Abstract】 Objective To exprore the efficacy and fafety of xinlekang pian in the treatment of insomnia . Merthod 53 insomniacs were randomly divided into the traditional Chinese medicine (TCM,n=31,orall took xinlekang pian)group and control group (n=22,did alprazolam ) for 4 weeks. The clinical efficacy were assessed with the Sleeping Questionnnaire(SQ)and adverse effects with the Clinical Global Im-pression(CGI)before treatment and the end of the 2nd and 4th week treatment.Results At the end of the 4th week, excellence rates were respectively 54.1% of the TCM group and 59.1% of the control group(P>0.05);Compared with pretreatment, since the end of the 2nd week SQ scores of the two groups lowered very significantly(both P<0.01) and gradually did along with treatment lasting; there were no significant differences in synchronization comparisons between the two groups(P>0.05).Adverse effects were obviously lower in the TCM than in the control. Conclusion Xinlekang pian is equivalent to alprazolam and has fewer adveres effects, higher safety and better compliance in the treatment of insomnia. ......
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