纳洛酮在慢性阻塞性肺疾病并呼吸衰竭治疗中作用(1)
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【摘要】 目的 观察纳洛酮治疗AECOPD 并发Ⅱ型呼吸衰竭的临床疗效。方法 将65例病例随机分为治疗组及对照组，两组均予以积极控制感染，持续低流量吸氧，解痉平喘，止咳化痰，营养支持等综合治疗。治疗组在此基础上加用纳洛酮注射剂，首剂负荷量0.8 mg 加入生理盐水20 ml中静脉推注,以后给予纳洛酮注射剂2 mg加入生理盐水100 ml中,缓慢持续静脉滴入, 12 h/次, 24 h纳洛酮总剂量为4 mg,连用3 d。结果 治疗组总有效率显著高于对照组(P<0.05 )；动脉血气分析指标：动脉血氧分压(PaO2)显著高于对照组(P<0.05)、动脉血二氧化碳分压(PaCO2)显著低于对照组(P<0.05)；结论 纳洛酮治疗AECOPD合并呼吸衰竭临床疗效确切。
【关键词】纳洛酮；慢性阻塞性肺部疾病； Ⅱ型呼吸衰竭
The effect of naloxone in treating COPD with respiratory failure
【Abstract】 Objective To observe the clinical effectof naloxone in treatment of AECOPD with type Ⅱ respiratory failure. Methods The 65 patientsof AECOPD with type Ⅱ respiratory failure were randomly divided into target group 33 and control group 32. Both were treated with regular drug therapy. The target group was given naloxone injection 2 mg intravenous drip for 3 days. Results After treatment, the overall effective rate in the targetgroup was significantly higher than that in the control group (P<0.05). Conclusion Naloxone is effectivefor treatment of AECOPD with typeⅡ respiratory failure. ......
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