复方甲磺酸帕珠沙星滴眼液的制备及质量控制(1)
【摘要】 目的 制备复方甲磺酸帕珠沙星滴眼液，并建立质量控制方法。方法 以甲磺酸帕珠沙星、氯化钠、地塞米松磷酸钠、羟苯乙酯制备复方甲磺酸帕珠沙星滴眼液;采用高效液相色谱法测定其中甲磺酸帕珠沙星的含量。结果 甲磺酸帕珠沙星检测浓度在20.0～80.0 μg/ml范围内线性关系良好(r=0.999 9)，平均回收率为97.7%(RSD=1.96%，n=6)。结论 本方法简便﹑准确﹑重现性好，可用于甲磺酸帕珠沙星滴眼液的质量控制。【关键词】甲磺酸帕珠沙星;滴眼液;制备;质量控制
Preparation and quality control of compound pazufloxacin mesilate eye drops
ZHAN Feng,LI Jin-wei, HE Xi-kui,et al. Zhengzhou Hospital of Traditional Chinese Medicine，Zhengzhou City， Henan450007,China
【Abstract】 Objective To prepare compound pazufloxacin mesilate eye drops and a to establish a method of it’s qualit control. Methods Compound pazufloxacin mesilate eye drops were parepared with pazufloxacin mesilate , sodium chloride , dexamethasone sodium phosphate , and ethylparaben . The content of moxifloxacin h drochloride was d etermined by HPLC. Results A linear calibration curve for assay of Pazufloxacin mesilate was obtained in the range of 20.0~80.0 μg/ml(r=0.999 9) and the average recoveries were 97.7% (RSD=1.96% n=6). Conclusion Formation technique is simple and quality can be controled ......
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