【摘要】 血浆脂蛋白相关磷脂酶 A2(LP-PLA2)由成熟的巨噬细胞和淋巴细胞合成和分泌，又称血小板活化因子乙酰水解酶 (PAF-AH)，在血浆中主要与低密度脂蛋白结合。近年来，越来越多研究表明在动脉粥样硬化的发病机制及预防性治疗上，LP-PLA2是动脉粥样硬化中的一个新的炎性反应标志物，可能成为冠心病治疗的新靶点。

    【关键词】 脂蛋白相关性磷脂酶 A2；动脉粥样硬化；冠心病

    【Abstract】 Lipoplrotein-associated phospholipase A2(Lp-PLA2)，also named platelet- activating factor，synthesized and secreted by ripe macrophage and lymphocyte，which are transported in human plasma mainly bound together with low-density lipoprotein.Research in rerent years indicates the necessity of studying Lp-PLA2 as a new inflammatory marker factor in pathogenesis and prophylactic treatment of atheroselerosis.and Lp-PLA2 may become an new therapeutic target of coronary heart disease.

    【Key words】 Lipoplotein-associated phospholipaseA2；Atheroselerosis；Coronary Heart Diseae

    动脉粥样硬化(atherosclerosis ......