结合卵胞浆内单精子显微注射治疗阻塞性无精子症患者39例(2)
患者采用PESA 或TESA结合ICSI治疗了39个周期,获得了受精率76%和累积临床妊娠率53.84%的良好结果,在治疗的过程中还发现,该类患者临床妊娠率较同期因输卵管/盆腔因素行体外受精胚胎移植的患者妊娠率高[1],这可能是因为无精症患者的女方通常是具有正常的生育力,其排卵功能和内膜接受性是正常的。总之,PESA 或TESA结合ICSI 可以有效的治疗阻塞性无精子症患者的不育,使他们也可能获得自己生物学意义上的子女。但是,由于这些技术可能会使其后代患有父辈的遗传缺陷,故应该对接受治疗的患者进行遗传学咨询,必要时还需要对其早期胚胎进行植入前遗传学诊断,以提高健康婴儿的出生率,减少和预防遗传性疾病的出现。
参 考 文 献
[1] 孙秀芹,李瑞梅,牛焕付,等.体外受精胚胎移植124周期临床分析.济宁医学院学报,2005,2(28):34-35.
[2] Palermo G,Joris H,Devroey P,et al.Pregnancies afterintracytoplamic injection of single spermatozoon into anoocyte.Lancet,1992,340 (8810):17-18.
[3] Li M,Zhuang GL,Li R,et al.Intracytoplasmic injectionwith sperm from ejaculation,epididymis and testitis intreating differentmale infertilitywith oligoasthenozoospermiaor ozospermia.Zhonghua Waike Za Zhi,2000,38(4):280-282.
[4] Li PS,Goldstein M,Scheyel PN.Which operationalmethod is better for obtaining sperm? National J Andro,2001,7(2):71-78.
[5] Silber SJ,Balmaceda J,Borrero C,et al.Pregnancy withsperm aspiration from the proximal head of the epididymus:a new treatment for congenital absence of the vasdeferens.Fertil Steril,1988,50(3):525-528., 百拇医药(姚红梅 孙秀芹 牛焕付)
参 考 文 献
[1] 孙秀芹,李瑞梅,牛焕付,等.体外受精胚胎移植124周期临床分析.济宁医学院学报,2005,2(28):34-35.
[2] Palermo G,Joris H,Devroey P,et al.Pregnancies afterintracytoplamic injection of single spermatozoon into anoocyte.Lancet,1992,340 (8810):17-18.
[3] Li M,Zhuang GL,Li R,et al.Intracytoplasmic injectionwith sperm from ejaculation,epididymis and testitis intreating differentmale infertilitywith oligoasthenozoospermiaor ozospermia.Zhonghua Waike Za Zhi,2000,38(4):280-282.
[4] Li PS,Goldstein M,Scheyel PN.Which operationalmethod is better for obtaining sperm? National J Andro,2001,7(2):71-78.
[5] Silber SJ,Balmaceda J,Borrero C,et al.Pregnancy withsperm aspiration from the proximal head of the epididymus:a new treatment for congenital absence of the vasdeferens.Fertil Steril,1988,50(3):525-528., 百拇医药(姚红梅 孙秀芹 牛焕付)