【摘要】 目的 探讨干扰素治疗诱发的甲状腺功能减退症的临床特征。方法 选2004-2008年收治的干扰素治疗诱发甲状腺功能减退症12例(A组)，回顾性分析住院期间的临床资料，并采用门诊随访方式了解其出院后的治疗情况。取同期病毒性肝炎合并甲减患者(未用干扰素)11例作为对照组(B组)。结果 两组肝功能指标及血清总三碘甲腺原氨酸(TT3)、血清总甲状腺素(TT4)指标无统计学差异，B组患者促甲状腺激素(TSH)值较A组患者明显增高P=0.034，差异有统计学意义，A组给予干扰素治疗3个月~3年后，平均(13±8.78)个月出现甲减，8例患者需长期给予左甲状腺素片替代治疗。结论 干扰素治疗诱发产生甲减时，应及时停用干扰素，以避免产生永久性甲减。

    【关键词】干扰素；甲状腺功能减退症(甲减)；病毒性肝炎；促甲状腺激素

    【Abstract】 Objective To explore the clinical feature of hypothyroidism induced by interferon.Methods 12 hypothyroidism patients induced by interferon hospitalized in our hepatopathy unit(time from 2004-2008) were selected for research(A group).We analyzed the hospitalized data retrospectively and followed up the therapy circumstance in out-patient clinic.The eleven viral hepatitic patients complicated with hypothyroidism (none interferon use) were chosen as control group(B group) at same time.Results The hepatic function and TT3,TT4 had no significant difference in two groups.The TSH in B group was significantly raised compared to A group(P=0.034).The patients in A group appeared hypothyroidism after interferon therapy for three to three years(13±8.78 months in average).Eight patients needed Levothyroxine for replacement therapy in perpetuum.Conclusion We should stop interferon use when induced hypothyroidism in order to avoid permanent hypoparathyroidism. ......